Genomic variants-driven drug repurposing for tuberculosis by utilizing the established bioinformatic-based approachShort communication Published on 2022-12-012022-10-05 Journal: Biochemistry and Biophysics Reports [Category] 신약개발, [키워드] annotations applied approach bioinformatics biological process CCR5 CD44 cellular component contribute CXCR4 demonstrated deregulation disease disease-associated drug Drug discovery Drug repurposing drug target evaluated Evidence facilitate functional functional annotation Genes genomic genomic variant genomic variants GWAS HLA-B identify implementation in-silico indication involved KEGG Missense mutation molecular overlapped Pathogenesis Pathway analysis provided risk SELP suggested target Treatment Tuberculosis variant [DOI] 10.1016/j.bbrep.2022.101334 [Article Type] Short communication
Autoantibodies – enemies, and/or potential allies?Article Published on 2022-10-192022-11-15 Journal: Frontiers in Immunology [Category] 진단, [키워드] antibody Antigen autoantibodies autoantibody Autoimmune Autoimmune disease Autoimmune diseases binding Biomarker Cancer caused COVID COVID - 19 COVID-19 Diagnosis diagnostics disease Disease diagnosis disease-associated global pandemic Host include positive predict Prognosis self-antigens stability Symptom therapy Treatment Treatment. [DOI] 10.3389/fimmu.2022.953726 PMC 바로가기
Systems Bioinformatics Reveals Possible Relationship between COVID-19 and the Development of Neurological Diseases and Neuropsychiatric DisordersArticle Published on 2022-10-162022-11-16 Journal: Viruses [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Acidic acute respiratory syndrome Analysis app Autoimmunity bioinformatics biological processe Combination contribute coronavirus COVID-19 development disease disease-associated disorder disorders dysregulation epitope Epitopes genetic risk factor GFAp Host identify incidence include increased risk indicated Infection linear MAPT microtubule-associated protein modulated molecular molecular mimicry motif Multiple Myasthenia network biology neurodegenerative Neurodegenerative diseases neurological Neurological disease Neurological diseases Neurological disorder Neuropsychiatric neuropsychiatric disorders PPI precursor Protein protein-protein interaction Proteins receptors recognize relationship SARS-CoV-2 SARS-CoV-2 epitope SARS-COV-2 infection sclerosis sequence similarity System systems bioinformatics. [DOI] 10.3390/v14102270 PMC 바로가기
A human iPSC-array-based GWAS identifies a virus susceptibility locus in the NDUFA4 gene and functional variantsArticle Published on 2022-10-062022-11-16 Journal: Cell Stem Cell [Category] COVID19(2023년), SARS, 변종, [키워드] cause Cell Cluster Dengue dengue virus disease-associated functional variant genome-wide association Genome-wide association study GWAS Human genetics identify indicated individuals Infection iPSC array isogenic hiPSC lines leakage of mtDNA locus Loss mitochondrial mtDNA NDUFA4 non-risk allele polymorphism provide risk risk allele SARS-CoV-2 SARS-COV-2 infection screening strategy sensitivity Signaling single-nucleotide single-nucleotide polymorphism SNP SNPs Stress susceptibility type I interferon type I interferon. upregulation viral infection viral infectivity virus Zika virus ZIKV [DOI] 10.1016/j.stem.2022.09.008 PMC 바로가기
Obesity is associated with a higher Torque Teno viral load compared to leannessArticle Published on 2022-09-282022-11-15 Journal: Frontiers in Endocrinology [Category] 진단, [키워드] 95% CI acute respiratory syndrome Affect age Analysis association Bariatric surgery BMI confounder coronavirus coronavirus disease disease disease-associated Diseases fasting insulin Follow-up Host immune function immunocompetence in viral independent individual Infectious disease interleukin 6 IQR linear modeling marker median obese obesity outcome outcomes participant PCR positively correlated proportion quantified reflect rising risk risk factor risk stratification subjects torque torque teno virus viral immune response Viral load virus vitamin D levels weight loss Weight loss. [DOI] 10.3389/fendo.2022.962090 PMC 바로가기
Single-nucleus RNA sequencing reveals the shared mechanisms inducing cognitive impairment between COVID-19 and Alzheimer’s diseaseArticle Published on 2022-09-232022-11-16 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, [키워드] AD-high-risk scores Alzheimer’s disease Astrocyte Cell cell population cognitive Cognitive impairment COVID-19 COVID-19 patients demonstrated disease disease-associated dysfunction GWAS identify mechanism Neuroinflammation Neuron neuronal pathway proteomic reported reveal RNA sequencing RNA-sequencing SARS-CoV-2 SARS-COV-2 infection single-nucleus RNA sequencing. subtype synaptic syndrome target therapeutic intervention transcriptomic [DOI] 10.3389/fimmu.2022.967356 PMC 바로가기
Correlates with Vaccine Protective Capacity and COVID-19 Disease Symptoms Identified by Serum Proteomics in Vaccinated IndividualsArticle Published on 2022-09-132022-11-15 Journal: Molecules [Category] SARS, 변종, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome Algorithm allergy Analysis Asymptomatic autoantibodies autoantibody biological processes Biomarker Capacity caused characterized circulating Cohort coronavirus coronavirus disease correlated COVID-19 disease disease severity disease-associated effective intervention Efficacy epitope Evidence Genetic HBV Identified Immunoglobulin immunology implementation individual individuals mechanism non-severe cases pandemic PCR-negative PCR-positive PCR-positive individual profile Protective Protein Proteins proteomic proteomics purpura Quantitative RBD reducing response to vaccination risk SARS-CoV-2 severe disease severe symptom spike receptor-binding domain Symptom thrombosis understanding uninfected vaccinated individual Vaccine Vaccine development vaccine. virus transmission virus variant viruses with COVID-19 [DOI] 10.3390/molecules27185933 PMC 바로가기
Single-cell transcriptomics reveals common epithelial response patterns in human acute kidney injuryArticle Published on 2022-09-092022-11-15 Journal: Genome Medicine [Category] 유전자 메커니즘, 진단, [키워드] Acute kidney injury adverse outcomes affected AKI Cell cell type changes in characterized Control COVID-19 criteria Critical Critical illness Critically ill patient diagnosed with COVID-19 disease disease-associated distal epithelial Gene Expression heterogeneity highlighting histology human kidney humans hypoxia Improving individual Injury inter-individual interferon response KDIGO kidney Kidney injury kidney tissue limbs mechanism molecular molecular responses occur oxidative stress performed Post-mortem provide proximal resource respiratory infections response reveal Sequencing single-cell sequencing. Single-cell transcriptomics subtype Therapies Transcriptome transcriptomic transcriptomics [DOI] 10.1186/s13073-022-01108-9 PMC 바로가기
Implicating effector genes at COVID-19 GWAS loci using promoter-focused Capture-C in disease-relevant immune cell types질병 관련 면역 세포 유형에서 프로모터 중심 Capture-C를 사용하여 COVID-19 GWAS 유전자좌에서 이펙터 유전자 관련Article Published on 2022-06-032022-09-11 Journal: Genome Biology [Category] COVID19(2023년), SARS, 변종, [키워드] Adaptive immune response approach attenuate B cell broad spectrum chromatin condition COVID COVID-19 COVID-19 disease COVID-19 disease severity Critical Critical illness death differentially expressed disease disease severity disease-associated e genes element exacerbate functional GART Genes genetic component Genome-wide association study genomic GWAS High-resolution Hospitalization human genetic variation IFNAR2 Immune cell immune cell type immune cells implicated in viral Inflammation interferon interferon response involved life-threatening limit loci magnitude Mild Moderate COVID-19 no symptom OAS1 OAS3 offer Patient PAXBP1 Replication risk SARS-CoV-2 SARS-COV-2 infection target the interferon Therapeutics TNFAIP8L1 variant viral replication [DOI] 10.1186/s13059-022-02691-1 PMC 바로가기 [Article Type] Article
Analyzing single cell transcriptome data from severe COVID-19 patients중증 코로나19 환자의 단세포 전사체 데이터 분석Article Published on 2022-04-212022-09-11 Journal: STAR protocols [Category] MERS, 바이오마커, 유전자 메커니즘, 진단, [키워드] bioinformatics Cell cell type cell types cellular Complete COVID-19 COVID-19 severity database detect disease-associated enrichment analysis Gene Expression Genomics Health Sciences identify immunology in silico in vitro in vivo marker gene Molecular biology protocol Regulatory resources RNAseq RNAseq. severe COVID-19 severe COVID-19 patient Single Cell single-cell Transcriptome transcriptomics upregulated upregulation [DOI] 10.1016/j.xpro.2022.101379 PMC 바로가기 [Article Type] Article